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Webb18 jan. 2011 · AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity Activation of the PI3K-AKT pathway in tumors is modulated by negative feedback, including mTORC1-mediated inhibition of upstream signaling. Webbintestine, the percentage of inhibition was 68.18%, 87.22% and 91.91%, respectively. The inhibiting action of sodium orthovanadate (100 µmol/L) was stronger than that of the same dosage of acarbose (70.37%) ( P<0.05, Table 1). Table 1 Inhibitory effect of sodium orthovanadate on α-glucosidase activity in small intestine (mean±SD, n = 8) WebbA cell culture system was used to investigate the mechanism of action of the feedback … phoenix xmas light shows