Klf4 microglia

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August undefined, 2024

WebApr 14, 2024 · 102.KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress. ... 191.Chimeric GPCRs mimic distinct signaling pathways and modulate microglia responses. WebMay 6, 2024 · KLF4 is expressed in a variety of cell types including monocytes/macrophages. Previous reports have demonstrated that KLF4 is expressed in microglia and functions as a downstream factor of TLR signaling, plays critical roles in microglial activation, and ensuing neuroinflammation [ 38, 39, 40, 41 ].

Frontiers The Role of KLF4 in Alzheimer’s Disease

WebApr 12, 2024 · HIGHLIGHTS. who: Nikita Arnst et al. from the Department of Biomedical Sciences, University of Padova, Padua, Italy have published the article: Mitochondrial Ca2+ Signaling and Bioenergetics in Alzheimeru2024s Disease, in the Journal: Biomedicines 2024, 10, 3025. of /2024/ what: In this review the authors focused on Ca2+ alterations in AD … WebJun 4, 2024 · The Intra-nuclear SphK2-S1P Axis Facilitates M1-to-M2 Shift of Microglia via Suppressing HDAC1-Mediated KLF4 Deacetylation Sphingosine 1-phosphate (S1P) is … how to add idx to your website

Cocaine-Mediated Downregulation of miR-124 Activates Microglia …

WebMar 2, 2024 · MiR-146a-5p in DG regions is associated with depression-like phenotypes and suppression of neurogenesis via the KLF4/CDKL5 pathway (A) Schematics of AAV vectors engineered to overexpress miR-146a-5p or knockdown miR-146a-5p … WebJul 30, 2024 · Microglia restrain potential damage to the central nervous system and support tissue repair and remodeling, under the inflammatory conditions of an active immune response. They can phagocytosis... WebSep 21, 2024 · KLF4 plays a crucial role in regulating pro-inflammatory signals. In glial cells, gemfibrozil-induced KLF4 activation increases suppressor of cytokine signal 3 (SOCS3) … methodist olive branch women\\u0027s center

National Brain Research Centre, Manesar, Haryana, India

MIF-CD74 signaling impedes microglial M1 polarization and

WebApr 30, 2024 · Mechanistically, we identify Kruppel-like factor 4 (KLF4) as a key transcription factor that regulates cardiac resident macrophage proliferation and angiogenic activities. Finally, we show that blood-borne macrophages recruited in late-phase POH are detrimental, and that blockade of their infiltration improves myocardial angiogenesis and ... WebApr 3, 2024 · Microglia, a population of resident macrophages derived from erythro-myeloid progenitors of the yolk sac ... AHR enhances KLF4 expression and suppresses NF-κB signaling in TAMs. methodist olive branch ob gynWebDec 22, 2015 · LPS has been widely used to study the molecular mechanisms of microglial activation in inflammatory neurodegeneration (1–3).In primary monocultures and … methodist olive branch patient portal

"WebNov 24, 2024 · iPSC-Derived Microglia for Modeling Human-Specific DAMP and PAMP Responses in the Context of Alzheimer’s Disease. ... Klf4 and c-Myc are involved in cell proliferation, and c-Myc is also a well-known protooncogene. Therefore, it was more than necessary to look for new possibilities and combinations of factors whose application … " - Klf4 microglia

Klf4 microglia

Unbound IRF2 to IRF2BP2 mediates KLF4 signaling leading to anti ...

WebMicroglia have been recognized as macrophages of the central nervous system (CNS) that are regarded as a culprit of neuroinflammation in neurodegenerative diseases. Thus, microglia have been considered as a cell that should be suppressed for maintaining a homeostatic CNS environment. However, microglia ontogeny, fate, heterogeneity, and … Web包含至少一个检索词. 不包含检索词. 出现检索词的位置

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WebSep 21, 2024 · KLF 4 is a zinc finger-containing nuclear protein, isolated from NIH 3T3 library and located in the cell nucleus. It was first identified and characterized by Shields et al. (1996). The molecular mass of human KLF 4 is 55kD and it is located on the chromosome 9q31. KLF 4 covers a 6.3 kb gene segment and has five exons. WebDec 1, 2024 · Studies also have showed that KLF4 is a response factor for SCI and expresses higher level than that of sham animals [ 8 ]. The involvement of KLF4 in SCI may be its regulatory role in microglial activation and subsequent neuro-inflammation [ 9 ]. Moreover, the therapeutic strategy targeting on KLF4 abrogates microglial activation [ 10 ].

WebAug 9, 2013 · KLF4 inhibited the formation of a vascular network in implanted Matrigel plugs in nude mice. Importantly, we found that KLF4 significantly upregulated the miR-15a … WebMay 28, 2024 · Microglia is one of the inflammatory cells in the central nervous system (CNS), which plays a diverse role via polarizing into two main states, namely, classically activated M1 and alternatively activated M2 ( 81 ). Brain-specific miR-124 is expressed in microglia in the normal CNS and during experimental autoimmune encephalomyelitis (EAE).

WebJun 4, 2024 · KLF4 is important for many different physiological processes, including cell development, stem cell self-renewal, and maintenance of normal tissue homeostasis ( 19 ). Recently, KLF4 has been identified directly bind to promoter region of Agr1, then accelerate its transcription and microglial M2 polarization. WebApr 15, 2024 · The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB Signaling Pathway - ScienceDirect …

WebApr 15, 2024 · The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB Signaling Pathway - ScienceDirect Neuroscience Volume 488, 15 April 2024, Pages 102-111 Research Article The Novel KLF4/BIG1 Regulates LPS-mediated Neuro-inflammation and Migration in BV2 Cells via PI3K/Akt/NF-kB …

WebDec 11, 2024 · KLF4 is a vital regulator of macrophage polarization. Studies have shown that KLF4 expression is observably elevated in M2 macrophages and observably reduced in … how to add idm to microsoft edgeWebNov 12, 2024 · For exam- ple, KLF4 inhibits ischemic stroke-induced apoptosis of cere- bral microvascular endothelial by activating MALAT1 (30). Moreover, KLF4 is a key regulator of macrophage polarization (18) and can regulate microglial activation and subsequent neu- roinﬂammation(16). methodist omaha mychartWebNov 23, 2007 · Krüppel-like factor 4 (KLF4/GKLF/EZF) is a transcription factor involved in both the regulation of proliferation and differentiation in several tissues (1, 2, 3, 4).As a negative regulator of the cell cycle, KLF4 3 activates the expression of p21 Cip1/WAF1, a cyclin-dependent kinase inhibitor (), and represses the expression of cyclin B 1 ().KLF4 is … methodist omaha careersWebAug 9, 2024 · KLF4 has been suggested to facilitate the recruitment of transcriptional machinery even to genes within compact chromatin. 31 With KLF4 transactivation of Ch25h in the context of atheroprotective flow, we next examined the epigenetic modulations involved in such activation of the Ch25h gene. how to add id using javascriptWebJun 4, 2024 · Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor expressed in a wide variety of tissues. KLF4 is important for many different physiological processes, … methodist omaha mychart loginWebJan 20, 2013 · Microglia are the tissue macrophages of the brain and scavenge dying cells, pathogens and molecules using pattern recognition receptors and subsequent phagocytosis and endocytosis 1, 2, 3. methodist omaha neurosurgeryWebNov 2, 2024 · The translocated IRF2 activated the transcription of Kruppel-like factor 4 (KLF4), causing KLF4 to be induced in BV2. The expression of KLF4 increased the CD206-positive cells in BV2. how to add idprt printer