NettetFor clonal diversification of TCR, a large number of T cell progenitors are required in which highly diverse TCRbeta chains are accommodated individually. In the present … Nettet11. mai 2007 · We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage. All hematopoietic cells are generated from a small subset of pluripotent stem cells (HSCs) via lineage-restricted progenitors. In adult mice, HSCs reside in the bone marrow (BM) …
Genome-wide Lineage-Specific Transcriptional Networks
Nettet15. okt. 1998 · Only lineage-restricted progenitors are found in FT. Single FcR − FT and Sca-1 + FL cells from 12-dpc fetuses were cultured under the MLP assay conditions for … Nettet8. aug. 2024 · Studies over the last 10 years identified LEPR + mesenchymal lineage cells as relevant cellular sources of SCF for HSCs and lineage-restricted hematopoietic … definition of pseudocoelomate
Are Leukaemic Stem Cells Restricted to a Single Cell Lineage?
Nettet5. nov. 2015 · In FL, the ratio of cells with multilineage versus unilineage potential remained constant in both the stem cell (CD34 + CD38 –) and progenitor cell (CD34 + CD38 +) enriched compartments.By contrast, in BM, nearly all multipotent cells were restricted to the stem cell compartment, whereas unilineage progenitors dominated … Nettet23. apr. 2014 · The discovery of stem and progenitor cells in the adult mammalian heart has added a vital dimension to the field of cardiac regeneration. Cardiac-resident stem cells are likely sequestered as reserve cells within myocardial niches during the course of embryonic cardiogenesis, although they may also be recruited from external sources, … NettetFirst, cDC-committed progenitors do exist in the BM, confirming a “pre- commitment” to the cDC lineage at early stages of DC development as proposed previously (Liu et al., 2009). definition of pseudodementia