Lysosomal phospholipase a2

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August undefined, 2024

WebLysosomal phospholipase A2 (LPLA2), also known as phospholipase A2 Group XV, is the only enzyme so far to be mechanistically linked to phospholipidosis. LPLA2 knockout mice present similar features seen in drug-induced phospholipidosis including foam cells with lamellar inclusion bodies and surfactant lipid accumulation 5. WebA phospholipase A₂ was identified from MDCK cell homogenates with broad specificity toward glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, …

Lysosomal Phospholipase A2 Is Selectively Expressed in Alveolar ...

WebThe lysosomal phospholipase A2 (LPLA2 ) is specifically expressed in macrophages. LPLA2 gene deletion in mice causes lysosomal phospholipid accumulation in tissue … Web16:0-02:0 PC might be used in liposomes to study the hydrolyzing action of lysosomal phospholipase A2 (LPLA2) on truncated oxidized phosphatidylcholine in vitro. Packaging. 5, 25 mg. 5 mL Clear Glass Sealed Ampule (880622C-25mg) 5 mL Clear Glass Sealed Ampule (880622C-5mg) dead stock swedish utility pt

Lysosomal phospholipase A2 and phospholipidosis - PubMed

WebThe phospholipase A2, termed 1- O -acylceramide synthase or lysosomal phospholipase A2 (LPLA2) 1 has the following properties. In the presence of ceramide, the enzyme … WebLYPLA3, also known as Group XV phospholipase A2, is an enzyme that in humans is encoded by the PLA2G15 gene.. Lysophospholipases are enzymes that act on biological … National Center for Biotechnology Information deadstock quilting fabric

The phospholipase A2 activity of peroxiredoxin 6 [S]

Web4 mar. 2024 · Lysosomal phospholipase A 2 (LPLA 2 /PLA2G15) is a key enzyme involved in lipid homeostasis and is characterized by both phospholipase A2 and transacylase activity and by an acidic pH optimum. Divalent cations such as Ca 2+ and Mg 2+ have previously been shown to have little effect on the activity of LPLA 2, but the … Web1 ian. 2011 · The lysosome is an intracellular acidic compartment containing more than 50 digestive enzymes including proteases, nucleases, glycosidases, phosphatases, … general electric in wilmington ncWebMCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。Group XV phospholipase A2/Pla2g15, Mouse (His, myc) MCE 国际站：Group XV phospholipase A2/Pla2g15, Mouse (His, myc) Synonyms: Group XV phospholipase A2; 1 … deadstock sweatshirts

"Web24 mai 2016 · Whole-lipid extract (20 100nmol phospho-lipid) driedunder nitrogengas. driedlipid 6.2mg/ml osmium tetraoxide carbontetrachloride 15min roomtemperature. reactionmixture driedunder nitrogengas, redissolved chloroform/methanol (20:1, vol/vol), aluminacolumn (0.6 activatedneutral aluminum oxide, 150 mesh) preequilibrated … " - Lysosomal phospholipase a2

Lysosomal phospholipase a2

Parkinson’s Disease-Related Genes and Lipid Alteration

Web14 oct. 2024 · PLA2G6 encodes calcium-independent phospholipase A2 ß (iPLA2β), ... Among these, mitochondrial dysfunction and deposits in the endo-lysosomal pathway are the most commonly observed, suggesting that similar pathways are important in the development of different NDs. Thus, sphingolipids can serve as a link between … WebPLA2G6 encodes a calcium-independent group VI phospholipase A2, which localizes to the neuronal mitochondria and endosomal and lysosomal membranes. In the nervous system, PLA2G6 could be essential for the remodeling of membrane phospholipids in axons and synapses; however, the exact molecular mechanism by which PLA2G6 contributes …

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Web13 feb. 2013 · The nature of the self-antigens involved in the development and maturation of iNKT cells is poorly defined. Lysophospholipids are self-antigens presented by CD1d that are generated through the action of phospholipases A1 and A2. Lysosomal phospholipase A2 (LPLA2, group XV phospholipase A2) resides in the endocytic system, the main site … WebHuman lysosomal phospholipase A2 (LPLA2, also known as Lp-PLA2 or PLA2G15) is responsible for normal lipid metabolism and it is unique from other known PLA2s in that …

WebPhospholipidosis, the excessive accumulation of phospholipids within lysosomes, is a pathological response observed following exposure to many drugs across multiple … http://www.uscnk.cn/uscn/Recombinant-Lysophospholipase-III-(LYPLA3)-RPF623Hu01.htm

Web1 aug. 2024 · Lysosomal phospholipase A2 (PLA2G15) is a ubiquitous enzyme uniquely characterized by a subcellular localization to the lysosome and late endosome. Web1 oct. 2006 · Lysosomal phospholipase A 2 (Lpla2) is highly expressed in alveolar macrophages and may mediate the phospholipid metabolism of surfactant. Studies on …

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WebStructure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase. Nat Commun, 6:6250-6250, 2015. Cited by . PubMed: 25727495 DOI: 10.1038/ncomms7250 general electric jeff immeltWeb2 mar. 2015 · Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharacterized family of key lipid-metabolizing … general electric invented the light bulbWeb26 oct. 2024 · No PS subspecies was completely resistant to enzymatic hydrolysis. 29 Recently, putative phospholipase B-like-2 (PLBL2) was ruled out as the root cause of inducing PS hydrolysis in protein formulation through both genetic knock-out and immunedepletion of PLBL2. 30 The confl icting reported results are likely due to the … deadstock releasesWeb16:0-02:0 PC might be used in liposomes to study the hydrolyzing action of lysosomal phospholipase A2 (LPLA2) on truncated oxidized phosphatidylcholine in vitro. Envase. 5, 25 mg. 5 mL Clear Glass Sealed Ampule (880622C-25mg) 5 mL Clear Glass Sealed Ampule (880622C-5mg) general electric job postingsWebEchelon’s Lysosomal Phospholipase A2 (LPLA2) Activity Assay is a homogenous assay designed to detect activity from biological and purified sources of LPLA2. This in vitro, … general electric iron vintageWebHuman lysosomal phospholipase A2 (LPLA2, also known as Lp-PLA2 or PLA2G15) is responsible for normal lipid metabolism and it is unique from other known PLA2s in that LPLA2 is only active in an acidic environment (~pH 4.5). general electric icicle lightsWeb磷脂酶A2(phospholipaseA2 PLA2)是一种能催化磷脂甘油分子上二位酰基的水解酶，亦是花生四烯酸(AA)、前列腺素及血小板活化因子(PAF)等生物活性物质生成的限速酶，所产 … general electric jobs cincinnati ohio