Rnf4 sumo

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August undefined, 2024

WebNov 22, 2013 · The SAXS data of the tetra-SUMO2-RNF4-SIMs domain complex indicate that it exists as an ordered structure. The HADDOCK model showed that the tandem RNF4 … WebPML degradation [4,10]. RNF4 was initially described as a SUMO-targeted ubiquitin ligase (STUbL) [21]. This RING finger protein [22] colocalizes with SUMO1 in PML NBs [23] and …

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WebNov 27, 2024 · SUMO-targeted ubiquitin ligases (STUbLs) mediate the ubiquitylation of SUMOylated proteins to modulate their functions. In search of direct targets for the STUbL … Web× Close. The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. http://genesdev.cshlp.org/content/26/11/1179 flight service station salary

Structural analysis of poly-SUMO chain recognition by the RNF4 …

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required

WebRNF4 is mammalian homologue of MIP. RNF4 interacts with hSMEK2, the human homologue of Dictyostelium SMEK. We propose the existence of an evolutionarily … WebI am glad our teamwork by Emile Alghoul and Jihane Basbous, in collaboration with the teams of Alessandro Barducci and Pierre Henri-Gaillard, is now online. The focus is on the … flight service station privatizationWebStructural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain. C. Kung, M. Naik, +7 authors Tai-Huang Huang; Biology ... flight service stations frecuencies

"WebDec 4, 2012 · The SUMO-targeted ubiquitin E3 ligase, RNF4, is a potentially important factor involved in integrating ubiquitin and SUMO signals at sites of DNA damage. RNF4 is … " - Rnf4 sumo

Rnf4 sumo

Analysis of SUMOylated proteins using SUMO-traps - PMC

WebArsenic degrades PML or PML/RARA via a sumo-triggered RNF4/ubiquitin-mediated pathway. Nature Cell Biology mai 2008 RXR is an essential component of the oncogenic PML/RARA complex in vivo. Cancer Cell juil. 2007 Dimerization-induced ... WebRNF4 depletion or proteasome inhibition led to accumulation of mixed, polyubiquitinated, poly-SUMO chains. PML protein accumulated in RNF4-depleted cells and was …

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WebMay 7, 2024 · SUMO chain formation and the StUbL pathway are induced in response to proteotoxic or genotoxic stress (Jansen and Vertegaal, 2024). Under proteotoxic stress … WebCompartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair. In this study, Alghoul et al. show that the Fanconi anemia protein SLX4 forms globular clusters of …

WebMar 9, 2024 · We report that SLX4 compartmentalizes the SUMO-RNF4 signaling pathway. SENP6 and RNF4 regulate the assembly and disassembly of SLX4 condensates, … WebJun 29, 2010 · Here we show that RNF4 (RING finger protein 4), a SUMO-dependent ubiquitin E3-ligase previously implicated in maintaining genome stability, plays a key role in active …

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WebSep 20, 2024 · SLX4 condensates compartmentalize the SUMO system and the STUbL RNF4 to enhance selectively the modification of substrate proteins by SUMO and ubiquitin. …

WebInterferon (IFN) is a crucial first line of defense against viral infection. This cytokine induces the expression of several IFN-Stimulated Genes (ISGs), some of which act as restriction … flight service station frequenciesWebExcept these studies, I was also involved in solving structures of SUMO chain, type II topoisomerase and transglycosylase in complex with chemical compounds. During few … flight service stations auoWebSep 18, 2024 · Similarly, RNF4 has been shown to regulate the SUMO- and ubiquitin-mediated proteasomal degradation of a mutant cystic fibrosis transmembrane … cheng and talwar ddsWebRT @MolecularCell: Online Now: Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair. 14 Apr 2024 01:06:10 cheng and chen keyinghamWebSep 30, 2024 · The SUMO-Targeted Ubiquitin Ligases (STUbL) mediate this process, and RNF4, the mammalian STUbL, has been at the forefront in the understanding of this … cheng and lowWebSep 18, 2012 · This is consistent with the increased interaction of RNF4 with PML isoforms in response to As 2 O 3, an agent known to induce poly-SUMOylation (as seen in Fig. 1B), … flight service websiteWebWe show herein that Rnf4, an E3 ubiquitin ligase that targets SUMO-modified proteins, accumulates in DSB repair foci and is required for both homologous recombination (HR) … flight service weather briefer