Thermosensitive in situ gel

Author: ylye

August undefined, 2024

Webb21 maj 2024 · To develop thermosensitive in situ gel formulations for nasal use, the transition temperature must be set in the range of 25-37°C [ 17 ]. The most common … Webb8 maj 2024 · Optimised in-situ drug-containing gel with multifactorial approaches showed promising ocular formulation having minimum side effect and high therapeutic efficacy. Objective: The present study has focused on development and optimization of thermosensitive in-situ ocular drug delivery system for the treatment of conjunctivitis. …

Advanced Nanocomposite Hydrogels for Cartilage Tissue …

Webb2 okt. 2014 · The purpose of this study was to develop a buccal paclitaxel delivery system using the thermosensitive polymer Pluronic F127 (PF127) and the mucoadhesive polymer polyethylene oxide (PEO). The anticancer agent paclitaxel is usually used to treat ovarian, breast, and non-small-cell lung cancer. Webb3 sep. 2024 · The in situ gelation properties of the formulation upon administration in the nasal cavity were investigated in terms of gelation time and temperature. It was found … horknee definition

Development and characterization of a novel mucoadhesive sol-gel …

Webb1 aug. 2024 · Temperature sensitive in-situ gel, at room temperature stands in a liquid state and with an increase in temperature to body temperature it thickens to gel form … Webb29 apr. 2024 · In response to changes in temperature, thermosensitive hydrogels can convert from solution to gel (sol-gel) state. Given that the ambient temperature is usually lower than the physiological temperature, this can be used as a … WebbBiodegradable and injectable in situ thermosensitive hydrogels were investigated for sustained delivery of pro- tein therapeutics in the treatment of ocular posterior segment neovascular diseases. A series of triblock (TB, polycaprolac- tone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL), B-A-B) and pentablock copolymers (PBCs) (polylactic … horklump location hogwarts legacy

Thermosensitive In Situ Gel Based on Solid Dispersion for Rectal ...

Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery

Webb11 apr. 2024 · A novel drug delivery system for topical application of thermosensitive hydrogel loaded with IgY and LL37-SLNs composite was design 3 2 full factorial design, prepared and characterized.. Thermosensitive hydrogel loaded with IgY and LL37-SLNs were used for in situ injection and sequential release.. The optimized formulation was … Webb1 feb. 2024 · The aim of the current study was to formulate thermosensitive in situ gel nanoemulsions (NEs) containing acyclovir (ACV) for ocular drug delivery and evaluate their ex vivo corneal permeation ability and ocular irritation possibility. ACV loaded NEs were prepared by low energy method. losbor oneWebb2 sep. 2024 · Hydrogels are three-dimensional networks composed of hydrated polymer chains and have been a material of choice for many biomedical applications such as drug delivery, biosensing, and tissue engineering due to their unique biocompatibility, tunable physical characteristics, flexible methods of synthesis, and range of constituents. In … horknight watchman dragon quest 11

"Webb26 maj 2024 · Viability assay on retinal cells displayed that fluconazole nanoemulsion in-situ gel formulation was non-toxic and can be safely used in the eye at concentrations of 0.1% and 0.5%. ... Z. Development of thermosensitive in situ gel nanoemulsions for ocular delivery of acyclovir. J Drug Deliv Sci Technol 2024; 55: 101400. Google Scholar " - Thermosensitive in situ gel

Thermosensitive in situ gel

Development and characterization of a novel mucoadhesive sol-gel …

WebbThe thermosensitive hydrogel immediately formed at body temperature can make the drug concentrated within the tumor site and less transferred to other organs and tissues, thus lessening damage to normal organs and tissues. Webb7 feb. 2024 · The aim of this work was to formulate an ST rectal hydrogel. Methods: Hydrogels were formulated according to a Box–Behnken design using pluronic F-127 (PF-127) and chitosan as thermogelling and mucoadhesive agents, respectively. The rectal permeability was examined using a sheep rectal mucosa.

Did you know?

WebbThermosensitive in situ gel preparations can be applied to nasal, ophthalmic, injection, and vaginal preparations, with the aim to increase the contact time of the formulation when it is applied. Keywords: Thermosensitive in situ gel, Poloxamer, Kitosan, Nasal, Ophthalmic, Injection, Vaginal. Abstrak. Webb1 feb. 2024 · The aim of the current study was to formulate thermosensitive in situ gel nanoemulsions (NEs) containing acyclovir (ACV) for ocular drug delivery and evaluate …

Webb7 maj 2016 · phase transition from sol-to-gel phase in situ gelling systems can be categorized into following three types:11,18 pH triggeredin situ gelling polymers:pH triggered in situ gelling systems are solutions, which upon exposure to the pH of the lachrymal ﬂuid converts into the gel phase e.g. such as cellulose acetate WebbThe gel temperature of 1% MC solution was observed at 60°C. It was found that 6% oral rehydration salt without dextrose (ORS) was capable to reduce the gel temperature …

Webb8 nov. 2024 · Thermosensitive polymer solutions that exhibit a sol-gel phase transition near body temperature after injection can prolong drug retention by providing a depot … WebbXie et al 45 synthesized a novel poloxamer-based thermosensitive in situ gel system for the sustained delivery of NCTD via intratumoral administration to treat liver cancer. Consequently, the thermosensitive hydrogel exhibited good thermal sensitivity and the gelation temperature was 34 °C.

WebbSilver sulfadiazine nanosuspension-loaded thermosensitive hydrogel as a topical antibacterial agent Xiaoya Liu, Hui Gan, Chaoran Hu, Wenzhong Sun, Xiaoxia Zhu, Zhiyun Meng, Ruolan Gu, Zhuona Wu, Guifang Dou Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, People’s Republic of China …

WebbBioadhesive-Thermosensitive In Situ Vaginal Gel of the Gel Flake-Solid Dispersion of Itraconazole for Enhanced Antifungal Activity in the Treatment of Vaginal Candidiasis. … los brackets bandcampWebbThermosensitive hydrogel, which can form gel in situ at the body temperature, is especially useful as a depot for the delivery of therapeutics with minimal invasiveness [9,10]. Therapeutic drugs or cells can be easily mixed in the sol-phase of the hydrogels before injection and be stably released from the gel-phase inside the body. hork randimalsWebb18 sep. 2015 · To address these problems, we developed a thermosensitive in situ gel based on poloxamer 407 for local uterine administration. To achieve the desired gelling … losbp.tvscredit.comWebb1 juli 2012 · The results concluded that thermosensitive liquid in-situ gelling suppositories of Metoclopramide Hydrocloride were effective, potential, and more convenient alternative for a conventional oral dosage form that was given for emetic patients; thereby improving patient compliance and medication adherencet. 3 PDF View 1 excerpt, cites methods los borrachos motorcycle clubWebbPurpose: Thermosensitive in situ gels have been around for decades but only a few have been translated into ophthalmic pharmaceuticals. The aim of this study was to combine … horkoffWebb28 feb. 2024 · Enhanced photo/chemo combination efficiency against bladder tumor by encapsulation of DOX and ZnPC into in situ-formed thermosensitive polymer hydrogel Zhongming Huang Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China, … los botas in english horknee meaning